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KMID : 0364819760140040151
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Korean Journal of Microbiology
1976 Volume.14 No. 4 p.151 ~ p.158
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Mutagenicity of nitrofuran, nitroimidazole and nitrothiazole derivatives on salmonella/ microsome system
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Abstract
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Using Ames´Salmonella/microsome system, mutagenicity of antirichomonal nitrofuran, nitroimidazole, and nitrothiazole derivatives was examined. Nitrofurantoin, nifuratel, furazolidone, metronidazole, nimorazole, ornidazole, and aminitrozole showed potent mutagenicity en TA100 strain which is a base substitute mutant and contains R-factor plasmid pKM101 without microsomal enzyme activation. In addition, nifuratel, furazolidone, metronidazole, and ornidazole also induced frameshift mutation in TA98 strain.
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KEYWORD
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